Moving bioanalysis from a reagent-centric to a data-centric approach

Simple

Powerful

Future-Proof

Changing tomorrow

If you are an innovator and see value in adding first-mover advantage to your research, QESLab Collaboration is for you!

 

QESLab is a rolling grant program that funds projects to use the QES platform early. We seek to build meaningful collaboration in diverse fields, to yield meaningful insights.

 

Accelerating the pace of research in biosciences.

The data gap between biology and AI models of biology

AI is causing a profound impact in biology and Healthcare through the convergence with math and engineering.

 

Current analytical technologies produce low-fidelity or fragmented views of biological systems that are difficult to scale and integrate. This creates a data gap and prevents the holistic understanding of complex and deeply interconnected biological systems.

A multi-disciplinary approach to fuel the AI revolution

Probius’ Quantum Electrochemical Spectroscopy (QES) creates a unique digital twin of biological specimens by representing its biochemistry as an ensemble of vibrational signatures.


These datasets can be federated into digital models of biology to accelerate the pace of biomedical research, from early disease discovery to drug development and therapy monitoring.

Enabling the decentralized and scalable collection of consistent biological datasets for the first time

To solve the bIology-AI gap, we have developed a new, label- and probe-free electrochemical sensing modality, Quantum Electrochemical Spectroscopy (QES), for the rapid detection 1000’s of analytes from a minimal sample amount in a few minutes.

Applications

Biomarker Discovery

Accelerate the discovery of disease pathways with broad-spectrum signatures from proteins, metabolites, and cells in days and not months. 

On-demand and On-the Cloud Multiplex Assay

Instant replication of experiments with new bioanalytical measurements on the cloud, without using a new sample aliquot.

Pre-clinical Model Organisms

Drive efficiency in your experimental model with a reagent-free approach that requires only 2.4ul of sample.

QC in Bioproduction and Synthetic Biology

Assess the purity and quality of your product without the need for analyte-specific reagents and workflows.

Frequently Asked Questions

QES stands for Quantum Electrochemical Spectroscopy. QES leverages the knowledge from an old spectroscopic technique called IETS (Inelastic Electron Tunneling Spectroscopy) to measure the vibrational frequency of the electrons of a molecule, which can be used as a fingerprint. IETS is a very powerful technique but was deemed impractical for everyday use because it requires ultra low temperatures to operate. QES overcomes these limitations and makes the principles of IETS practical and accessible to all.

Molecules are made of atoms, and atoms contain electrons, protons, and other particles. Electrons get pulled and pushed by different forces and “vibrate” as if they were attached to the atom by a spring. The vibrational frequency of the electrons in a molecule can be used as a fingerprint to identify and quantify that molecule. QES can determine the vibrational frequencies of different species in a sample, and with the help of different standards, can determine what is it and how much the sample has.

QES combines principles of electrochemistry and physics to make representations of biological samples tractable by AI algorithms. QES records the electron charge transfer at the quantum level to infer the vibrational frequency of electrons. This information is recorded at different steps and summarized into a file. This file is then processed by the Probius Bioanalytical cloud services and made accessible to the user through the software for on-demand analysis.

We have tested whole blood, serum, plasma, culture broth, and food samples, among other samples.

The sample amount depends on the matrix or sample type. For example, only 2ul of whole blood and 4ul of serum are required.

Each MiniQES instrument has six vials that can be used in each run. Given the simple operation, multiple instruments can be used simultaneously, increasing the throughput to run samples in parallel.

We have detected and quantified proteins like cytokines and liver enzymes, oligonucleotides, peptides (e.g.insulin), metabolites (e.g. glucose), small molecule drugs, glucose, and microorganisms like Salmonella and Staph Aureus, among others.

Data gets acquired in ~30 min per run. Each run can acquire six samples in parallel.

Yes, QES is not limited to human samples. We have tested QES measurements in liquid samples and suspensions from mice, rats, humans, culture broth, buffers, etc. The advantage of QES is that it does not require specific reagents like antibodies, which tend to be specific for each specie.

Yes, QES is not limited to human samples. We have tested QES measurements in liquid samples from mice, rats, humans, culture broth, buffers, etc. the advantage of QES is that it does not require specific reagents like antibodies, which tend to be specific for each specie.

Currently, we have started our early access program and there are 2 available options: 

 

  1. Our Research Grant Program is called QESLab. Here academic researchers can get access to a MiniQES instrument and consumables to collaborate with Probius in breakthrough applications. To chat with us, please leave us your details here.

  2. for those who are not an academic researcher, we have established an early access program, to get you moving with QES before it is broadly available. This program has similar intent, but different terms. Please contact us here.