QES Signal Transduction Mechanism

Electronic Feedback Amplification

In this peer-reviewed paper the design of the low noise potentiostat and circuit are described.

The potentiostat enables high resolution and broad range transduction of vibrational information.

IEEE Solid-State Circuits Letters

Low-Noise Integrated Potentiostat for Affinity-Free Protein Detection With 12 nV/rt-Hz at 30 Hz and 1.8 pArms Resolution.

This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications for personalized medicine. The affinity-free sensing technique uses a digital classifier to identify molecules through unique vibrational signatures. The sensing mechanism relies on coherent interference of electron wave functions at the interface between a nanoscale working electrode and a liquid electrolyte. Coherence at the sensing interface is enabled by low-noise feedback, which reduces the effective temperature of the electrons. The described three-channel potentiostat IC uses chopping and correlated double sampling to achieve an input-referred voltage noise of 12 nV/rt-Hz at 30 Hz and a current resolution of 1.8 pArms with 0.5-s averaging time. Each channel consumes 5 mW and occupies 0.41 mm 2 in 65-nm CMOS.

Sean Fischer , Dante Muratore, Stephen Weinreich, Aldo Peña-Perez, Ross M. Walker, Chaitanya Gupta, Roger T. Howe, and Boris Murmann

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