Electronic Feedback Amplification
In this peer-reviewed paper the design of the low noise potentiostat and circuit are described.
The potentiostat enables high resolution and broad range transduction of vibrational information.
IEEE Solid-State Circuits Letters
Low-Noise Integrated Potentiostat for Affinity-Free Protein Detection With 12 nV/rt-Hz at 30 Hz and 1.8 pArms Resolution.
This letter presents a low-noise integrated potentiostat for affinity-free molecular detection in applications for personalized medicine. The affinity-free sensing technique uses a digital classifier to identify molecules through unique vibrational signatures. The sensing mechanism relies on coherent interference of electron wave functions at the interface between a nanoscale working electrode and a liquid electrolyte. Coherence at the sensing interface is enabled by low-noise feedback, which reduces the effective temperature of the electrons. The described three-channel potentiostat IC uses chopping and correlated double sampling to achieve an input-referred voltage noise of 12 nV/rt-Hz at 30 Hz and a current resolution of 1.8 pArms with 0.5-s averaging time. Each channel consumes 5 mW and occupies 0.41 mm 2 in 65-nm CMOS.
Sean Fischer , Dante Muratore, Stephen Weinreich, Aldo Peña-Perez, Ross M. Walker, Chaitanya Gupta, Roger T. Howe, and Boris Murmann