Biological systems are complex and highly dynamic1. Genetics provides the blueprint, proteins and metabolites are the effectors of health and disease. There are more than 1,000,000 protein isoforms (proteoforms)2 and 200,000 metabolites, fluctuating in form and abundance in response to environmental changes, disease, and lifestyle.
Measuring this complexity at scale requires a new angle. To allow AI to truly impact Biosciences and Healthcare, we need an approach that breaks incrementalism and produces reliable data.
To address this challenge, Probius has taken inspiration from the sense of smell. This allowed us to create a versatile sensor that can cope with a broad range of analytes in a complex background.
1 Metwally, Ahmed A, Tom Zhang, Si Wu, Ryan Kellogg, Wenyu Zhou, Kevin Contrepois, Hua Tang, and Michael Snyder. “Robust Identification of Temporal Biomarkers in Longitudinal Omics Studies.” Edited by Jonathan Wren. Bioinformatics 38, no. 15 (August 2, 2022): 3802–11.
2 Aebersold, Ruedi, Jeffrey N Agar, I Jonathan Amster, Mark S Baker, Carolyn R Bertozzi, Emily S Boja, Catherine E Costello, et al. “How Many Human Proteoforms Are There?” Nature Chemical Biology 14, no. 3 (March 2018): 206–14.